Advances in Bioscience and Bioengineering

Advances in Bioscience and Bioengineering (ISSN 2201-8336) is a peer-reviewed journal that publishes papers in all aspects of Bioscience and Bioengineering, including but not limited to: Aerobiology; Anthropology; Biocatalysis; Biochemical Genetics; Biochemistry; Bioinformatics; Bioinformatics; Biological Engineering; Biological Evolution; Biomaterials; Biomathematics; Biomechanics; Biomedical Diagnosis; Biomedical technology; Biomedical Therapy; Biophysics; Bioprocess Design; Biostatistics; Botany; Cytobiology; Developmental Biology; Ecology; Entomology; Enzyme Engineering; Genetic Engineering; Genetics; Horizontal gene transfer; Immunology; Microbiology; Molecular Biology; Nano-Bio-Analysis; Neurobiology; Pathology; Physiology; Protein Engineering; Radiation Biology; Synthetic Biology; Tissue Culture Engineering; Virology; Zoology.

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Vol 7, No 1

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Simulated Microgravity Altered Hematological Indices Lipid Profile and Creatinine Kinase-Mb in Rattus Norvegicus PDF
Alaba Olumide Ojo, Lawrence Adedayo, Olatunbosun Onaseso, Olufemi Oluranti, Fidelis Ejeheri, Emmanuel Timothy

Several studies related to simulated microgravity via various means have been carried out. However, the effect that positive microgravity exerts on plasma lipid and heart are poorly understood. This study was carried out to determine the influence of simulated positive microgravity via hind limb suspension on hematological indices, lipid profile and the heart using creatinine kinase as a marker.

Twenty-four male wistar rats were randomly divided into four groups of six rat each. Group 1 -Normal control, Group 2-Frutose control group, Group 3-Suspended animal without fructose diet and Group4-Suspended animals given fructose diet. After two weeks the animals were euthanized with chloroform, blood samples were collected via cardiac puncture and analyzed.

A significant increase in total white cell counts was observed, though, the amount of lymphocytes in group3 (60.833±11.523) was significantly lower than the control (group 1) (91.317±1.246). Also there were significant reduction in PCV and hemoglobin concentration of group3 compared to the control (group 1). There was no significant alteration in plasma lipid profile and creatinine kinase-MB.

Thus, positive microgravity simulation significantly altered hematological indices, but insignificantly affected plasma lipid profile and creatinine kinase-MB.

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