Antimicrobial Activity of Some Medicinal Plants against Multi Drug Resistant Human Pathogens

Author(s): Al Nayem Chowdhury, M. Ashrafuzzaman, Hazrat Ali, Lutfun Nahar Liza, Kazi Mohammad Ali Zinnah

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The present study was conducted with a view to evaluate the therapeutic potentials of twenty six plant extracts traditionally used in Bangladesh against human pathogenic bacteria Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis by disc diffusion method. Out of twenty six plant extracts eight crude plant extracts namely Allamanda cathartica (leaf), Allium sativum (bulb), Citrus limon (fruit), Tamarindus indica (fruit), Prunus domestica (Fruit), Averrhoa carambola (fruit), Piper betle (leaf) and Terminalia arjuna (leaf) were found to exhibit potential antimicrobial properties against the isolated human clinical bacterial isolates whereas twelve plant extracts were failed to show any antibacterial activity against any of the isolates of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa followed by ten plant species in case of Proteus mirabilis. The maximum antimicrobial activity was found up to 80% in Tamarindus indica in case of Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis isolates meanwhile it is Averrhoa carambola which exhibited maximum activity against Escherichia coli isolates. Among the plant species tested, Tamarindus indica showed the most promising result. These results demonstrate the antimicrobial potential of the plants and hence lend support for the use of them in traditional medicine. Sensitivity of the bacterial isolates was also evaluated for eight commercial antibiotic discs where most of the isolates found to develop resistance against multiple commercial antibiotics. Among the antibiotics used, ciprofloxacin was the most effective one.

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